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Its fair to assume that in GLP-1 patients undergoing significant weight loss it will be even less predictable, Byrne said.

Although long-acting GnRH agonists suppress the release of LH and testosterone, GnRH agonists initially produce a rapid and transient increase in LH and testosterone levels, which is called the flare-up phenomenon, and may lead to side effects, such as bone pain and cardiovascular complications

Within the first few weeks, she noticed that her cravings had diminished significantly, making it easier for her to stick to her dietary goals

National prescription drug spending grew 10% in 2024 alone, and GLP-1 medications are now estimated to account for 14% of all prescription drug spending in 2026